Survey of Clinician Understanding of Susceptible Dose-Dependent Interpretations and Prescribing for VRE Infections

The Clinical and Laboratory Standards Institute recently updated the MIC breakpoints of daptomycin for E.faecalis and E.faecium, including a new "susceptible-dose dependent" category where isolate susceptibility is contingent on the dose of daptomycin. The effectiveness of the new SDD category in directing clinicians to use higher-dose daptomycin strategies has not yet been evaluated. It is possible that the unfamiliar SDD category prompts clinicians to avoid daptomycin altogether. This study seeks to evaluate how "SDD" has been interpreted at the University of North Carolina Medical Center (UNCMC) and whether clinicians select therapy differently when microbiologic susceptibility is reported as "S" or susceptible or "SDD" or susceptible dose-dependent.