NO FEAR-BE: Barrett's Esophagus Ablation Study

This research study is looking at a newer treatment option for Barrett's Esophagus (BE) which uses Nitrous Oxide to freeze unwanted tissue. The most commonly used treatment method is Radiofrequency Ablation (RFA) which uses heat to destroy the pre-cancerous tissue. Nitrous Oxide ablation using the C2 CryoBalloon Focal Ablation System, an FDA cleared device, is another, newer way of treating Barrett's Esophagus. To evaluate the newer treatment, we are enrolling patients who are not responding as well as expected to RFA. Patients with at least 2 or more previous RFA treatments who still have BE may be eligible.