Study Details

Open

Osteoarthritis Prevention Study

The purpose of this research study is to identify strategies that may prevent the development of knee osteoarthritis.

Age & Gender

50 years ~ 99 years
Female

Visit Availability

Standard business hours (M-F, 8-5)
Extended hours (M-F, early morning or evening)

Location

North Carolina (Durham, Orange)

What will be asked of you

To determine if you are eligible, you will meet with a study team member who will ask you some questions and you will receive a knee xray. Then, if you are still eligible, you will receive a knee MRI at a separate visit. You will then be scheduled with a study team member for another visit to complete some questionnaires and physical function/strength tests. Eligible participants will then be randomized (like flipping a coin) to receive a 4-year diet and exercise program or a health education program and will be asked to participate in yearly study visits during the 4-year study. Depending on the program you are assigned to, there will be weekly and monthly diet and exercise (or health education) individual and group sessions to attend.

Incentives

You will be paid $140 via gift cards if you complete all the scheduled study visits. , knee xray and MRI; if assigned to diet and exercise group, a gym membership; nutrition and exercise or health education information

In-person visits:
8 to 9 study assessment visits then weekly and monthly classes depending on the group you are randomized to

Total length of participation:
48 months

Looking for Specific Volunteers

Able to participate:

you are overweight
you have no knee pain or occasional knee pain
you are willing to travel to the UNC Campus or Chapel Hill/Durham area for up to 2 days a week for 2 years

Not eligible if:

you have knee pain or diagnosed knee osteoarthritis
you are planning to leave the area > 2 months during the next 48 months
you have symptomatic or severe coronary artery disease
you are unable to provide own transportation to and from intervention site
you are unable to walk without a device

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Cortney Armitano-Lago
TOPS@email.unc.edu
(919) 966-8388

Primary Visit Location

MOTION Science Institute
Fetzer Hall (UNC-Chapel Hill)
210 South Rd, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Leigh Callahan
Medicine-UNCP A Rheumatology

Study Type

Behavioral or Social
Interventional

Study Topics

Aging
Behavior
Healthy Volunteer or General Population
Obesity
Wellness and Lifestyle
Women's Health
Movement
UNC or UNC Health employees

IRB Number

23-0673