Study Details

Open

PERMIT - PERsonalized BioMarkers for Immunotherapy Treatment

The purpose of this study is to learn about how drugs used to treat multiple myeloma (MM) work. The drugs used to treat MM can change how many of certain types of cells you have in your blood and bone marrow. These cells are part of your immune system. Also, MM and the drugs for MM may alter the immune function of your gut microbiome. The number of certain types of cells and the composition of your gut/fecal microbial can help researchers understand how your immune system is working.

Age & Gender

18 years ~ 99 years
Male, Female, Gender Inclusive

Visit Availability

Standard business hours (M-F, 8-5)
Visits can be combined with regular clinical appointments

Location

North Carolina (Statewide)

What will be asked of you

If you decide to participate in this study we will take extra blood and bone marrow at the times of your standard of care (SOC) blood draws. Also, we will ask you to bring your stool samples when you come into the clinic for bone marrow and blood draw. We will also ask you to fill out a short optional online 10-15 minute questionnaire on your dietary intake in the past month.

Total length of participation:
approximately 14 months

Looking for Specific Volunteers

Able to participate:

You have a confirmed or suspected diagnosis of either multiple myeloma or high-risk smoldering multiple myeloma.
You have had no prior chemotherapy for smoldering multiple myeloma within 18 months of enrollment and no prior chemotherapy for active multiple myeloma.
You would be a potential candidate for induction therapy per standard of care or via enrollment on a clinical trial.
You are willing to have extra bone marrow aspirate collected during standard of care bone marrow biopsies.
You are willing to have extra blood collected during standard of care blood draws.

Not eligible if:

You have dementia, altered mental status, or any psychiatric or co-morbid condition prohibiting the understanding or rendering of informed consent.

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Lineberger Clinical Research
cancerclinicaltrials@med.unc.edu
(919) 966-4432

Primary Visit Location

NC Cancer Hospital (Basnight)
UNC Hospitals / UNC Medical Center
101 Manning Dr, Chapel Hill, NC 27514, USA

Secondary Visit Location

UNC Hospitals Hillsborough Campus
460 Waterstone Dr, Hillsborough, NC 27278, USA

Additional Study Information

Principal Investigator

Eben Lichtman
LCCC - Clinical Trials

Study Type

Clinical or Medical
Observational

Study Topics

Blood Conditions
Cancer (Multiple Myeloma)

IRB Number

19-0658