Open

Radiation Therapy and Dry Mouth Study

The purpose of this study is to test the safety and effectiveness of a gene therapy called AAV2-hAQP1. This gene therapy will be used to help participants with dry mouth due to radiation therapy.

Age & Gender

18 years ~ 99 years
Male, Female

Visit Availability

Standard business hours (M-F, 8-5)

Location

United States (Nationwide)

What will be asked of you

At each monthly visit, you will be asked to complete assessments and provide your medical history. You will then receive the study drug in your salivary gland.

Incentives

Study Medication

In-person visits:
10

Total length of participation:
1 year

Looking for Specific Volunteers

Able to participate:

You completed radiation 3 years or more ago for head and neck cancer
You have no history of any other cancer

Not eligible if:

You have been a part of another research study within last 3 months
You have been previously treated with gene therapy
You currently smoke or have smoked within last 3 years
You have poorly controlled diabetes

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

NC Cancer Hospital (Basnight)
UNC Hospitals / UNC Medical Center
101 Manning Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Xuguang Chen
LCCC - Clinical Trials

Study Type

Clinical or Medical
Interventional

Study Topics

Cancer (Head and Neck)
Ear, Nose, and Throat

IRB Number

23-1424

ClinicalTrials.gov

NCT05926765

Copyright © 2013-2022 The NC TraCS Institute, the integrated home of the NIH Clinical and Translational Science Awards (CTSA) Program at UNC-CH. This website is made possible by CTSA Grant UL1TR002489 and the National Center for Advancing Translational Sciences.

Helpful Links

Questions?

This email address is being protected from spambots. You need JavaScript enabled to view it.