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Dupilumab for Eosinophilic Esophagitis with Severe Strictures (DESTRICT Study)

To determine the effect of an FDA-approved drug on treating patients with severe strictures and Eosinophilic Esophagitis (EoE)

Age & Gender

16 years ~ 99 years
Male, Female, Gender Inclusive

Visit Availability

Standard business hours (M-F, 8-5)

Location

United States (Nationwide)

What will be asked of you

At each visit you will complete questionnaires. You will be asked to complete an upper endoscopy (a procedure where a scope with a light and camera on the end are inserted into your mouth and down your throat to your stomach) 4 times during the study. Blood and biopsies (tissue samples) will be collected during each endoscopy visit. You will receive dupilumab administered under your skin weekly for 52 weeks, and you will be taught how to administer dupilumab yourself.

Incentives

Up to $400

In-person visits:
11

Phone or online visits:
1

Total length of participation:
Up to 64 weeks

Looking for Specific Volunteers

Able to participate:

Are 16 years of age or older and weigh at least 40kg (88.2lbs)
Have been diagnosed with Eosinophilic Esophagitis (EoE)
You have active Eosinophilic Esophagitis (EoE)
Your EoE has not responded to other medications or therapies
You've had at least 4 dilations for stictures, at least 2 in the past year

Not eligible if:

You have other eosinophilic GI conditions (eosinophilic gastritis, enteritis, or colitis)
You are allergic or intolerant to dupilumab
You've had part of your esophagus removed
You are pregnant or breastfeeding

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

Clinical and Translational Research Center (CTRC)
Burnett-Womack Building (UNC-Chapel Hill)
160 Dental Cir, Chapel Hill, NC 27514, USA

Secondary Visit Location

UNC Meadowmont
300 Meadowmont Village Cir, Chapel Hill, NC 27517, USA

Additional Study Information

Principal Investigator

Evan Dellon
Medicine-Gastroenterology

Study Type

Clinical or Medical
Interventional

Study Topics

Stomach, Digestion and Gut Health
Ear, Nose, and Throat

IRB Number

23-2625

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