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Understanding Outcome Differences in Adolescents and Young Adults with Acute Lymphoblastic Leukemia (ALL)

The purpose of this study is to understand why there are differences in outcomes in adolescents and young adults treated for Acute Lymphoblastic Leukemia.

Age & Gender

15 years ~ 39 years
Male, Female, Gender Inclusive

Visit Availability

Standard business hours (M-F, 8-5)
Visits can be combined with regular clinical appointments

Location

North Carolina (Statewide)

What will be asked of you

If you decide to take part in this study you will be asked to refill your regular doses of 6-mercaptopurine (6MP) and methotrexate (MTX) in a special MEMS® medication bottle with TrackCap™. This cap and bottle system will help the study team to track when the medication bottle is opened. You will be asked to fill out a questionnaire at the beginning and end of the study. A small amount of blood will be collected along with your regular blood draws.

Incentives

In-person visits:
7

Total length of participation:
6 months

Looking for Specific Volunteers

Able to participate:

You have been diagnosed with ALL
You have Ph- precursor B-cell ALL or lymphoblastic lymphoma or T-cell ALL or Ph+ ALL.
You are receiving maintenance therapy with oral 6MP and MTX.
At the time of study enrollment, received less than 24 weeks of maintenance.
At the time of study enrollment, has less than 24 weeks remaining before end of maintenance.

Not eligible if:

You have Mature B-ALL (Burkitt leukemia).
Previously enrolled on a research study to measure or improve medication adherence.

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Lineberger Clinical Research
cancerclinicaltrials@med.unc.edu
(919) 966-4432

Primary Visit Location

UNC Hospitals / UNC Medical Center
101 Manning Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Andrew Smitherman
Medicine-Hematology

Study Type

Clinical or Medical
Observational

Study Topics

Cancer (Pediatric Cancers, Leukemia)
Child and Teen Health

IRB Number

20-3288

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Questions?

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