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Diabetes Weight Loss Study with Reduction in Hemoglobin A1C

In this study, we are comparing different doses of CT-868 to placebo to learn more about its effectiveness in decreasing Hemoglobin A1C and in decreasing weight in people with Type 1 diabetes who are overweight or obese.

Age & Gender

18 years ~ 99 years
Male, Female, Gender Inclusive

Visit Availability

Standard business hours (M-F, 8-5)

Location

North Carolina (Statewide)

What will be asked of you

At each visit, you will meet with a member of the study team complete assessments. The study also involves 8 fasting blood draws including 2 meal tolerance tests, 2 body/bone density scans, willingness to take the study medication regularly, and completing questionnaires and drug dosing diaries throughout the study.

Incentives

Information provided upon request, Continuous glucose monitor, blood glucose monitor, ketone meter, bone mineral density scan, body mass composition scan

In-person visits:
13

Phone or online visits:
8

Total length of participation:
6 months

Looking for Specific Volunteers

Able to participate:

You must be 18 years of age or older with a diagnosis of Type 1 diabetes for greater than 1 one year
Your BMI is 25 or higher
You have a Hemoglobin A1C between 7.0% and 9.5%
Currently treated with insulin for more than 6 months and using a continuous glucose monitor longer than 2 months
You do not smoke

Not eligible if:

Diagnosis of Type 2 Diabetes or any other type of diabetes
You had diabetic ketoacidosis or had a severe hyoglycemic episode within the past 3 months
You use insulin with a delivery method other than insulin pump or multiple daily injections
You have made significant diet and exercise changes within the past 3 months or weight gain or loss ≥5% within the past 3 months
You have had a major cardiac event or stroke within the past 6 months

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

UNC Eastowne Medical Office Building
100 Eastowne Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Klara Klein
Medicine-Endocrinology

Study Type

Clinical or Medical
Interventional

Study Topics

Diabetes

IRB Number

23-1480

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