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CAR-T cells targeting the kappa antigen for Relapsed/ Refractory mantle cell and indolent non-Hodgkin lymphomas

The purpose of this study is to establish a safe and effective dose of CAR-T cells for patients with relapsed or refractory mantle cell Lymphoma or other indolent Non-Hodgkin lymphoma

Age & Gender

  • 18 years ~ 99 years
  • Male, Female

Visit Availability

  • Standard business hours (M-F, 8-5)
  • Visits can be combined with regular clinical appointments

Location

North Carolina (Statewide)

What will be asked of you

Your blood will be collected so that the manufacturing process to make modified T cells can begin. The modified study cells will hopefully be more effective at killing your cancer cells than your body's normal immune cells. The study team will do blood tests and other procedures to confirm it is safe for you to get the modified study cells. If it is safe, you will complete three days of pre-treatment (chemotherapy) that will prepare your body to accept the study cells better. You will then receive the study cell infusion. You will have to stay near the hospital after infusion and will be seen frequently in clinic for follow-up visits that may include lab tests, imaging, or biopsies of your tumor. You will continue follow up visits based on how well you have responded to the study treatment.

In-person visits:
Minimum of 14 through first year of participation; likely more depending on side effects
Phone or online visits:
Visits all in person unless disease has worsened, then can be contacted by phone during follow up.
Total length of participation:
1 year for treatment and initial follow-up, long term follow-up for 15 years

Looking for Specific Volunteers

Able to participate:

  • You have been diagnosed with Non-Hodgkin lymphoma Relapsed/Refractory or Mantle Cell
  • You have relapsed or refractory disease after at least 1/2 prior line of therapies

Not eligible if:

  • You are taking corticosteroids at doses of 10 mg or more of prednisone
  • You have history of intolerance to fludarabine or bendamustine
  • You have active infection with HIV, HTLV, Hepatitis B or Hepatitis C
  • Weakened heart condition

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

Lineberger Comprehensive Cancer Center
NC Cancer Hospital (Basnight)
UNC Hospitals / UNC Medical Center
101 Manning Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Natalie Grover
LCCC - Clinical Trials

Study Type

Clinical or Medical
Interventional

Study Topics

Cancer (Lymphoma)

IRB Number

18-0726

ClinicalTrials.gov

NCT04223765

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