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Study of Triple Negative Breast Cancer with Residual Invasive Disease

In this study, we want to find out if a combination of medications (Sacituzumab Govitecan and Pembrolizumab) can improve outcomes and delay the return of cancer when compared to standard treatment. This study is for patients with triple-negative breast cancer (TNBC) who still have detectable disease after initial treatment and surgery.

Age & Gender

  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive

Visit Availability

  • Standard business hours (M-F, 8-5)

Location

North Carolina (Statewide)

What will be asked of you

At each visit, you will meet with a member of the study team to review your medications, any symptoms you may be experiencing, and receive a brief examination. The study also involves several blood draws, questionnaires, administration of intravenous drugs, possibly also oral drugs to take at home, 1 ECG and 2 ECHO scans, and tissue from initial and surgical biopsies.

In-person visits:
27-35
Total length of participation:
Approximately 24 weeks of treatment followed by up to approximately 9.5 years of follow up

Looking for Specific Volunteers

Able to participate:

  • You have residual invasive triple negative breast cancer (TNBC) in the breast or lymph nodes after treatment and surgery.

Not eligible if:

  • You have Stage IV (metastatic) breast cancer

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

UNC Rex Cancer Center
2901 Blue Ridge Rd, Raleigh, NC 27607, USA

Additional Study Information

Principal Investigator

Amanda Sherrod
UNC Hospitals - Rex

Study Type

Clinical or Medical
Interventional

Study Topics

Cancer (Breast)

IRB Number

23-0652

ClinicalTrials.gov

NCT05633654

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