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Measuring cancer cells in the blood of head and neck cancer patients receiving surgery

The purpose of this study is to measure circulating tumor DNA (cancer cells) in the blood of head and neck cancer patients prior to surgery and monitor how these levels change over time.

Age & Gender

18 years ~ 99 years
Male, Female

Visit Availability

Standard business hours (M-F, 8-5)
Extended hours (M-F, early morning or evening)

Location

North Carolina (Statewide)

What will be asked of you

We will ask for blood sample(s) prior to surgery and a piece of tumor for biopsy after surgery. Every three months, you may be asked to give blood at your in-clinic visit.

In-person visits:
16

Total length of participation:
About 2 years

Looking for Specific Volunteers

Able to participate:

Histologically confirmed squamous cell carcinoma of the head and neck, including the following subtypes: oral cavity, oropharynx, larynx
Must be planning to undergo gross total resection of the primary tumor with curative intent at UNC-CH hospital
Age ≥ 18 years of age on day of signing informed consent
p16 IHC or HPV negative HNSCC for oropharyngeal primary tumors only
Patients who receive adjuvant therapy with radiotherapy +/- chemotherapy based on either standard of care (SOC) or appropriate clinical trial

Not eligible if:

Have known evidence of metastatic HNSCC disease based on clinical or radiographic studies
You are pregnant opr nursing

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

Primary Visit Location

UNC Hospitals / UNC Medical Center
101 Manning Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Siddharth Sheth
Medicine- Oncology

Study Type

Clinical or Medical
Observational

Study Topics

Blood Conditions
Cancer (Head and Neck)

IRB Number

18-3322

ClinicalTrials.gov

NCT04099290

Copyright © 2013-2022 The NC TraCS Institute, the integrated home of the NIH Clinical and Translational Science Awards (CTSA) Program at UNC-CH. This website is made possible by CTSA Grant UL1TR002489 and the National Center for Advancing Translational Sciences.

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Questions?

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