Study Details

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A Screening Study to Collect Samples in Patients With Metastatic Solid Tumors

The purpose of this screening study is to collect samples to learn more about your cancer using two investigational diagnostic tests. We will use the results to find out if you meet the eligibility criteria and could enroll in a separate TScan treatment research study.

Age & Gender

18 years ~ 99 years
Male, Female, Gender Inclusive

Visit Availability

Standard business hours (M-F, 8-5)
Visits can be combined with regular clinical appointments

Location

United States (Nationwide)

What will be asked of you

After meeting with the study team and signing consent, you will provide a swab from the inside of your cheek for initial testing. If the results of the swab suggest you might be able to take part in the treatment study, you will come back to the clinic to provide a saliva sample and a tumor sample. You can provide a tumor sample from a previous biopsy if it is in the last 6 months. If you do not have a tumor sample, you will provide a fresh one with a biopsy.

Incentives

Study biopsy will be covered by the study sponsor, may be reimbursed for travel costs

In-person visits:
At least 1 visit, some participants will come back for a second visit

Phone or online visits:
None

Total length of participation:
At least 1 office visit, may be more visits depending on test results

Looking for Specific Volunteers

Able to participate:

Have an unresectable or metastatic solid tumor: head and neck cancer, cervical cancer, non-small lung cancer, melanoma, ovarian cancer, HPV+ anogenital cancer
Willing to provide a buccal swab for HLA testing
Willing to provide a saliva sample
Have access to a tumor block that is <6 months old or is willing to provide a fresh biopsy

Not eligible if:

Currently receiving anticancer therapy such as tumor resection or chemoradiation

Contact the Team

Visit Location

Contact & Visit Location

Primary Contact

WIll Pulley
will_pulley@med.unc.edu

Primary Visit Location

Lineberger Comprehensive Cancer Center
NC Cancer Hospital (Basnight)
UNC Hospitals / UNC Medical Center
101 Manning Dr, Chapel Hill, NC 27514, USA

Additional Study Information

Principal Investigator

Jared Weiss
LCCC - Clinical Trials

Study Type

Clinical or Medical
Observational

Study Topics

Cancer (Cervical, Head and Neck, Lung, Melanoma, Ovarian)

IRB Number

23-0901

ClinicalTrials.gov

NCT05812027