This phase III trial studies iobenguane I-131 or crizotinib and standard therapy in treating younger patients with newly-diagnosed high-risk neuroblastoma or ganglioneuroblastoma. Radioactive drugs, such as iobenguane I-131, may carry radiation directly to tumor cells and not harm normal cells. Crizotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving iobenguane I-131 or crizotinib and standard therapy may work better compared to crizotinib and standard therapy alone in treating younger patients with neuroblastoma or ganglioneuroblastoma.

This study aims to understand how individuals with stroke participate in the community in Southwestern China. Also, this study explores the barriers and facilitators of participating in the community for individuals with stroke in Southwestern China.

Conducting focus groups with Gen Z consumers to understand perceptions of the MLB and attending games. Findings will inform marketing communication recommendations to increase game attendance.

The purpose of the study is to determine if information about how public housing programs can increase recipient insecurity, and how information about this insecurity can contribute to a reduction in support for social policy among the general population.

The purpose of this study is to optimize social media messages to encourage people to connect with others. Our goal is to create messages that resonate with populations that face a higher burden of disease.

The primary objective of this study is to assess the efficacy of rifaximin SSD-40IR versus placebo to delay the occurrence of hepatic encephalopathy (HE)-related hospitalization.

Sanfilippo syndrome Type A or mucopolysaccharidosis type IIIA (MPS IIIA) is a rare genetic disorder caused by the deficiency of the lysosomal enzyme sulfamidase. Lack of this enzyme causes buildup of large sugar molecules called glycosaminoglycans (GAGs) in the lysosomes which leads to cellular dysfunction. The buildup of GAGs causes significant damage to the body and brain. This study is a multicenter, Phase 1/2 study to assess the safety, tolerability, and efficacy of they study drug DNL126, an enzyme replacement therapy, to provide the missing enzyme to the body. Up to 28 participants with MPS IIIA will participate in the study across multiple study sites .

To determine the helpfulness of using images of brain anatomy to educate patients about their cognitive disorders.

The purpose of this study is to figure out the best way to work with providers and staff who treat pregnant people with very high blood pressure. We will send a nurse to 20 clinics that provide prenatal care in the community. For 12 months, the nurse will train and coach staff on implementing guidelines for addressing severe blood pressure. Some of the training will use patient actors who need their blood pressure measured, or who come to the clinic with very high blood pressure. The nurse will observe the clinic team as they interact with the "pretend" patient, and talk to them afterwards about ways to improve care. We will collect data before, during, and after the nurse has worked in the clinic. Information from 1) observations, and 2) patient charts of people who have already delivered, will tell us if our efforts in the clinics made a difference.

Compare the ability of crowd-sourced amateurs in identifying and labeling complex constructs (here, the 4 Ps of Marketing) in user-generated content (here, Tweets) with that of generative AI (here, ChatGPT4) . Can generative AI match or even exceed crowd-sourced labels?