Develop cell culture lines from normal head and neck tissue for use in laboratory investigations of treatment response. Molecularly profile normal tissue against profiles of original tumors to validate their utility as cancer models.

We are conducting up to eight focus groups to learn about the experiences of people who provide group services to justice-involved people with mental health problems. The goal of this study is to learn about how to improve the development of a new intervention for justice-involved individuals with mental illness.

This phase 3 trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincristine (CV) in treating patients with newly diagnosed or previously untreated low-grade glioma (LGG) that does not have a genetic abnormality called BRAFV600E mutation and is not associated with systemic neurofibromatosis type 1. Selumetinib works by blocking some of the enzymes needed for cell growth and may kill tumor cells. Carboplatin and vincristine are chemotherapy drugs that work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. The overall goal of this study is to see if selumetinib works just as well as the standard treatment of CV for patients with LGG. Another goal of this study is to compare the effects of selumetinib versus CV in subjects with LGG to find out which is better. Additionally, this trial will

This study is a randomized, placebo-controlled, double-blind, multicenter Phase 2/3 study of patients, age 12 to 65 years (inclusive), with sickle cell disease (SCD) and the primary objectives are: 1) To assess the effectiveness of study drug in adolescent and adults with SCD as compared to placebo as measured by improvement in hemoglobin (Hb) 2) To characterize the effectiveness of study drug as compared to placebo on the annual rate of pain crises

We are evaluating the use of a standardized handoff tool during emergent situations for pediatric patients.

The COVID-19 pandemic is shifting everyday life for Americans with profound economic, health, and psychological consequences. The impact of these disruptions on cancer survivors specifically warrants investigation, as this population may be at increased risk for serious illness complication. The goal of the proposed COVID-19 Cancer Study (CovCS) is to establish the feasibility and acceptability of conducting a contact study on the COVID-19 experiences of cancer survivors in North Carolina. CovCS will determine feasibility and acceptability of conducting participant-contact research during the COVID-19 pandemic with cancer survivors (colorectal, lung, bladder, kidney, breast and prostate cancer) and controls.

The purpose of this study is to investigate if N-803, a new experimental drug that stimulates the immune system, is safe and tolerable when given alone and in combination with two new experimental drugs that are antibodies (natural proteins that the body makes in response to an infection) to HIV (the virus that causes AIDS), VRC07-523LS and 10-1074. This study will also look at how well HIV is controlled after stopping anti-HIV medications (also known as "ART") in persons who received N-803 alone or N-803 with VRC07-523LS and 10-1074.

This project will define findings of patients referred for colonoscopy following a positive Cologuard® test using retrospective analysis of one community Gastroenterology practice.

Purpose: To understand the experiences of employees during the Covid-19 pandemic and what factors may impact their behaviors and experiences post-pandemic.

The purpose of this study is to capture the perceptions of Library and Information Studies professionals as to if and how the Black Lives Matter protests impacted their workplace and profession. We will distribute a survey through various professional listservs to gather these perspectives.